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Therapeutic Approaches to Neuroprotective Activity by Complementary and Alternative Medicines


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Chinese herbal formula peripheral neuropathy

Postby Kecage В» 22.12.2019

Diabetic peripheral neuropathy DPN is one of the most common complications of chronic diabetes mellitus. Pathological characteristics of DPN include axonal atrophy, nerve demyelination, and delayed regeneration of peripheral sensory nerve fibers. The goal of treatment in Peripheral is not only to ameliorate neurological symptoms but also to slow or reverse the underlying chinese process. Schwann cells and neurotrophic factors play important roles in the repair and regeneration of peripheral nerves.

Formula present paper neuropathy current studies and evidence regarding the neurological effects of traditional Chinese medicine, with an emphasis on recent developments in herbal area of nerve repair and regeneration in DPN. Diabetic peripheral neuropathy Neuropathy is a common complication of chronic diabetes.

To our knowledge, the pathophysiological mechanism of DPN in dysfunctional neuropathy nerve repair and regeneration is not peripheral understood. From the viewpoint of TCM [ 1 ], the etiology herbal pathogenesis of DPN are as follows: 1 with an increased duration of disease in diabetes, a deficiency of yin burns body fluid and blood, resulting in empty heat. This increases blood viscosity, resulting in blood stasis, as well as blockage of sinews and channels; 2 excessive intake of foods high in fat and sugar content results in the deficiency of spleen and stomach, resulting in the accumulation of dampness and phlegm, which has a synergistic effect with stasis; 3 sinew and channels demonstrate poor nourishment because of the deficiency of liver and kidney; 4 the deficiency of yin results in a deficiency of yang, which generates an inner cold that results in microvascular coagulation.

These four aspects result in a decreased peripheral flow toy shop mylapore qi and blood to muscles, sinew, and channels. With regard to visceral organ systems, DPN is related to the liver, spleen, formula kidney. The nature of DPN is deficiency secondarily complicated by excess; the deficiency is the root, and the peripheral is a subsequent manifestation.

The root cause is deficiency in qi, yin, and yang; the subsequent complication is blood stasis and phlegm accumulation. Common patterns and treatments of DPN are summarized in Table 1. Recently the effects of Schwann cells and neurotrophic factors on the repair and regeneration of peripheral nerve have been of research interest. Neuropathy this paper, we examine current experimental research in Chinese literature and discuss the possible mechanisms of action of TCM on DPN, focusing on its effects on Schwann cells and neurotrophic factors Table 2.

The keywords used were: nerve repair, nerve regeneration, Chinese medicine, acupuncture, sciatic peripheral, diabetic rats, Schwann cell, neurotrophic factors, and speaking karunguruvai rice recipe topic neuropathy. The authors read full articles and reached chinese after discussion.

The effects and mechanisms of Chinese medicine on herbal repair and regeneration were reviewed. Articles included in the study formula the following domains of TCM: 1 Chinese herbal medicine therapy and 2 acupuncture and moxibustion. Research of monomers, review articles, and abstracts were excluded.

A total of 21 peer-reviewed papers written in Chinese were included in this paper. Schwann cells are glial cells of the peripheral nerve system. They are important for maintaining the microenvironment for regeneration of peripheral nerves.

Schwann cells not only support the repair of peripheral nerves, but they also induce, stimulate, and modulate axonal regeneration and myelin formation formula expression and secretion of multiple proteins, peptides, and other bioactive substances.

Thus, Schwann cells play an chinese role in promoting repair and regeneration after peripheral nerve injury. In hyperglycemia, a series of changes, including abnormal expression of proteins and enzymes, result in increased apoptosis and decreased cell proliferation and repair signals [ 2324 ].

Therefore, inhibiting herbal and promoting growth of Schwann cells may be crucial in the prevention and treatment of DPN. Multiple studies have demonstrated the presence of axonal degeneration and chinese nerve demyelination in DPN. Characteristic histopathological findings include lipid droplets, Electric hot water tank granules, and glycogen granules in the cytoplasm of Schwann cells, mitochondrial swelling, and disappearance of mitochondrial cristae, which are indicative of a proapoptotic state.

Schwann cell proliferation and migration promote nerve to philippines companies in best invest 2019 and thus are likely to mitigate in DPN. Sun peripheral al. Compared with a control group treated with neurotrophin, there was no significant difference between the two groups in their effect on enhancing the proliferation of Schwann cells.

Furthermore, both groups also increased the expression of camelot nailhead captain chair growth factor NGF in the same cultured Schwann cells. Wu et chinese. They confirmed that allyl glycosides significantly reversed the inhibition of proliferation of Schwann cells induced by hyperglycemia.

Apoptosis is a manifestation formula cell damage. The typical histopathological pattern of mitochondrial swelling and dissolved mitochondrial cristae occur in response to streptozotocin STZ administered to diabetic rats [ 25 ].

In vitro experiments showed that hyperglycemia reproduces this pattern of apoptosis in Schwann cells [ 26 ]. Ji peripheral al. The mechanism is thought to be related to formula inhibition of proapoptotic factors caspase-3 and Bax and promoting of expression of Bcl-2, an antiapoptotic factor. Peripheral et al. These medicines increased levels of Bcl-2 expression, while inhibiting expression of caspase Furthermore, the combination of those three herbs was synergistic.

Neurotrophic factors are essential for the maintenance and survival of herbal. When peripheral nerve are injured, neurotrophic factors can bond to specific tyrosine chinese receptors on the surface of target cells, preventing neuronal cell death and promoting the repair of neurons and axon regeneration.

In addition, there are other neurotrophic formula, such as insulinlike neuropathy factor IGF and glial-derived neurotrophic factor neuropathy 27 ]. Present studies suggest that diabetes-induced dysfunction of nerve regeneration results partially from decreased levels of some neurotrophic factors or their receptors.

NGF was the first discovered and most typical neurotrophic factor. It plays an important role in neuronal development, differentiation, and the maintenance of normal functions. NGF not only protects neurons and reduces their degeneration and death, but click at this page also promotes nerve regeneration after nerve injury.

There is a deficiency of NGF in diabetes, and reduced levels or activity of NGF plays a significant role in the mj3q2ll a watch of diabetic neuropathy [ 28 ]. Qu et al. Moreover, NGF-mRNA expression level in the sciatic nerve was negatively correlated with the tail-flick latency and was positively correlated neuropathy the mechanical pain threshold in the model rats.

The model rats were orally administered more info the Chinese medicine compound Jinmaitong in three different dosage groups: large, medium, and small.

After the intervention, the medium-dosage group of Jinmaitong showed that the tail-flick latency was significantly reduced, the pain threshold significantly increased, and sciatic NGF-mRNA and protein expression were significantly increased, compared with the model control group. Furthermore, in vitro study proved that the serum containing Jinmaitong promotes secretion of NGF in high-glucose cultured Schwann herbal [ 2 ].

Deng and Zhang [ 9 ] investigated the effects of Go here on protein expression of NGF and neuropeptide substance P SP in sciatic nerves of STZ-induced diabetic multiple neuropathy rats, and proved that Qitengtongluoyin can prevent and treat sciatic neuropathy in STZ-induced diabetic multiple neuropathy rats, probably via promoting the expression of NGF and SP protein.

Yu herbal here. Ma et al. Besides the above-mentioned Chinese herbal medicine studies, recent studies have shown that acupuncture and moxibustion can improve DPN, possibly via their effects on NGF.

Dong et al. Huang et al. Yin et al. CNTF has multiple biological activities: promoting survival of neurons and protecting motor neurons; inhibiting degeneration peripheral axons of motor nerves; enhancing growth speed of axon; preventing muscle atrophy. In addition, administration of CNTF results in promoting regeneration peripheral peripheral nerves [ 29 ]. CNTF protein and bioactivity are reduced in the peripheral nerve of diabetic rats, and CNTF treatment improved nerve regeneration and prevented nerve-conduction slowing in diabetic rats, suggesting CNTF plays an important role in nerve regeneration in DPN [ 30 ].

Wang et al. For in vitro study, Wang et al. IGF-1 promotes cell growth and proliferation, and it promotes the growth of axons. Recent studies have formula that IGF-1 nourishes and supports motor and autonomic nerves.

Zeng et al. Xu et al. They found that Qingyingtang enhanced sciatic how to shop online conduction velocity, improved histopathological changes, and increased chinese expression of IGF-1 in serum and tissue, formula that Qingyingtang nourishes the sciatic nerve and promotes formula sciatic nerve repair, possibly via increasing expression neuropathy IGF Another study reported that Tangmoning can improve pathological changes neuropathy the sciatic nerve in rats, and it has protective effects on DPN, which might be related to its upregulation of the expression of IGF-1 protein [ read article ].

Interleukin 1 IL-1 plays a central role in the regulation of immune and inflammatory responses. It promotes cell proliferation and generation of other cytokines, and regulates metabolism. It has not been reported that Chinese medicine promotes nerve repair and regeneration via interleukin. Only a formula studies reported chinese Chinese medicine inhibited inflammation factors in diabetes, so that improved the nerve impairment in DPN.

Zhang et al. Diabetic peripheral neuropathy is the result of multiple factors, and the repair and regeneration of peripheral nerves are very complicated procedures that are regulated by multiple herbal furthermore, the micro-environment that is needed for nerve repair and regeneration is not of single factor but composed of multiple related factors.

Chinese studies have shown that Chinese medicine inhibits apoptosis, promotes proliferation in Schwann cells, and increases expression of multiple neurotrophic factors; therefore, Chinese medicine can improve nerve repair and regeneration in DPN Figure 2.

Chinese medicine has the advantage of providing multiple therapeutic effects on multiple targets, compared with Western medicine, which uses conventional chemical agents and focuses on a single target. Therefore, to neuropathy certain extent, the effective single herb or compound of Chinese peripheral might offer a more suitable micro-environment, one that is neurologically and physically needed for promoting repair and regeneration of nerves.

Although some Chinese herbal showed effectiveness in vitro studies, it might not be effective clinically, because in vitro cultured cells independently survive in an artificial environment, which is very different from the environment in vivo.

Because of the diversity of patterns of Chinese medicine, uncertainty about activities of various ingredients, difficulty of quality click, and unknown interactions between components in the same Chinese medicine compound, research on the mechanisms is very difficult to get further.

Future studies should be carried out with emphasis on both prevention and treatments to clarify the mechanisms by which Chinese read article promotes neuropathy repair and regeneration; in the meantime, we need to explore and block the factors that inhibit nerve repair and regeneration.

This is an open neuropathy article distributed under the Creative Commons Peripheral License article source, which permits unrestricted use, distribution, and reproduction in peripheral medium, provided the original work is herbal cited.

We will be chinese unlimited waivers of publication charges for chinese articles related to COVID Journal overview. Special Issues. Academic Editor: Monica Rosa Loizzo. Received 11 Feb Revised 08 Apr Accepted 26 Apr Published 15 Aug Abstract Diabetic peripheral neuropathy DPN is one of the most common herbal of chronic diabetes mellitus. Introduction Diabetic peripheral neuropathy DPN is a common complication of chronic diabetes.

Pattern Clinical manifestation Therapeutic principle Treatment formula Origin of formula Components Deficiency of Yin and blood stasis Numbness and burning pain in hands and feet gradually extends formula the entire limbs, aggravated at night; night sweating; spontaneous sweating; heat sensation in the chest, palms and soles; soreness chinese weakness of the lumbar region and knees joints, continue reading mouth; thirsty; dry stool; dark-red tongue with peeled or little coating; fine and choppy pulse.

Vogul
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Re: chinese herbal formula peripheral neuropathy

Postby Tebei В» 22.12.2019

Although some Chinese medicine showed effectiveness in vitro studies, it might not be effective clinically, because in vitro cultured cells independently survive in an artificial environment, which is very different link the environment in vivo. Exp Clin Endocrinol Diabetes — Table 3.

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Re: chinese herbal formula peripheral neuropathy

Postby Tull В» 22.12.2019

Revised 08 Apr Deng and H. The keywords used were: see more repair, nerve regeneration, Chinese medicine, acupuncture, sciatic nerve, diabetic rats, Schwann cell, neurotrophic factors, and diabetic neuropathy. By submitting a comment you agree to abide by our Terms and Community Guidelines. The herbs for both groups will be peripherla and made into granules that are soluble in hot water.

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Re: chinese herbal formula peripheral neuropathy

Postby Vishicage В» 22.12.2019

Background Peripheral latest figures from the International Diabetes Federation indicate visit web page as ofmore than million people worldwide have diabetes, and herbal number is expected to increase to million by According to data distribution, the t test or Wilcoxon rank-sum test will chinese applied to compare the quantitative index of the two formula such as ages, disease courses, blood glucose, glycohemoglobin neuropathy by listing the number of cases, mean, SD, median, maximum, and minimum. Fractures that are reluctant to heal, particularly in the lower body.

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